Publications

2024

2023

• Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases
  Woldmar N., , Schwendenwein A., Kuras M. , Szeitz B. , Boettiger K. , Tisza A., László V- , Reiniger L. , Bagó A. G., Szállási Z. Moldvay J., Szász A. M. Malm J. , Horvatovich P., Pizzatti L. , Domont G. B., Rényi-Vámos F., Hoetzenecker F. , Hoda M. A. , Marko-Varga G., Schelch K. , Megyesfalvi Z., Rezeli M., B. Döme B., ESMO Open, 2023, 8, (1), 1-13
  Impact Factor: 4.43
• Unfolding the Secrets of Small Cell Lung Cancer Progression: Novel Approaches and Leveraging insights through Rapid Autopsies
  Megyesfalvi Z., Heeke S., Drapkin B. J., Schwendenwein A., Kovacs A., Boettiger K., Horvath L., Ernhofer B., Fillinger J., Renyi-VamosF., Aigner C., Schelch K., Lang C., Marko-VargaG., Van Loo P., Hirsch F. R., Dome B., , Cancer Cell, 2023. 41, 9, 1535-1540.
  Impact Factor: 38.585
• Prognostic importance of biomarkers associated with haemostatic, vascular and endothelial disturbances in acute coronary syndrome patients in relation to kidney function
  Mörtberg J., Salzinger B., Lundwall K. , Edfors R. , Jacobson S. H., Wallén H. N. , Jernberg T. , Baron T, Erlinge D., Andell P., James S., Eggers K.M. , Hjort M., Kahan T., Lundman P. , Tornvall P., Rezeli M. , Marko-Varga G., Lindahl B., and Spaak J., Int. J. Cardiol, 2023, 373, 64-71
  Impact Factor: 4.164
• Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases
  Kuras M., Betancourt L. H., Hong, R., Szadai L., Rodriguez Murillo JHorvatovich P., Pla I.,Ericsson J., Szeit B., Deszzc B., Welinder C., Sugihara Y., Ekedahl H., Baldetorop B., Ingvar C., Lundgren L., Lindberg H., Oskolas H., Horvath Z., Rezeli M., Gil. J., Appelqvist R., Kemeny L. V., Malm J., Sanchez A., Szasz A. M., Pawlowski K., Wieslander E., Fenyö D. Nemeth I. B., and Marko-Varga G., BioRx, 2023.
• Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry
  Timar J., Honn K. V., Hendrix M. J. C., Marko-Varga G., Jalkanen S., Cancer and Metast. Rev., 2023, Feb, 08. https://doi.org/10.1007/s10555-023-10087-1
  Impact Factor: 9.246
• Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer
  Valko Z., Megyesfalvi Z., Schwendenwein A., Lang C., Paku S. , Barany N. , B., Ferencz , Horvat-Rozszas A., Kovacs I., Schlegl E., Pozonec V. , Boettiger K., Rezeli M., Marko-Varga G., Renyi-Vamos F., Alireza Hoda M., Klikovits T. , Hoetzenecker K. , Grusch M., Laszlo V, Döme B., and Schelch K., 2023, British J. Cancer, 2023, 187,
  Impact Factor: 9.075
• Age-associated Differences in the Human Lung Extracellular Matrix
  Ngassie, M. L. De Vries, T. Borghuis, W. Timens, Don D. Sin D. Nickle, P. Joubert, P. Horvatovich7, Marko-Varga G., J.J. Teske, J.M. Vonk, R. Gosens, Y.S. Prakash, J.K. Burgess, C.A. Brandsma, 2023, Am. J. Phys-Lung Cell Mol. Phys. 2023, 324, 5, p. L799-L814 doi: 10.1152/ajplung.00334.2022
  Impact Factor: 6.011
• Regulation of human oocyte maturation in vivo during the final maturation of follicles
  Cadenas, J., Poulsen, L. C., Nikiforov, D., Grøndahl, M. L., Kumar, A., Bahnu, K., Englund, A. L. M. Malm J. Marko-Varga G., Pla, I., Sanchez A., Pors, S. E. & Yding Andersen, C., 2023, Human Reproduction. 38, 4, p. 686-700.
  Impact Factor: 6.353
• Improved Melatonin Dissolution Properties: A Way Forward for Treating Children with Sleep Disorders
  Gil, Jeovanis; Malm, Johan and Marko-Varga, György, 2023. In Dissolution Technologies 30(2). p.66

  2022

  • Prediction of early-stage melanoma recurrence using clinical and histopathologic features.
    Wan G., Nga Nguyen N., Feng Liu F., DeSimone M.S., Leung B. W., Rajeh A. ,Collier M. R., , Choi M. S. , Amadife M. , Tang K. , Zhang S. , Phillipps J. S. , Jairath R. , Alexander N. A. , Hua Y., Jiao M , Chen W., Ho1 D. , Stacey Duey1 , Németh I. B. , Marko-Varga G. , Gil Valdés J. , Liu D. ,. Boland G. M. , Gusev A. , Sorger P.L. , Yu K-H., and Semenov Y. R., “”, NPJ Prec. Oncol., 2022, 6, 1-16
    Impact Factor: 10.092
    
  • In-depth proteomic analysis reveals unique subtype-specific signatures in human small cell lung cancer.
    Szeitz B, Megyesfalvi Z., Woldmar N., Valkó Z., Schwendenwein A. , Bárány N., Paku S. , László V., Bugyik E., Lang C. , Szász A. M. , Pizzatti L. , Hoda M. A., Hoetzenecker K. , Marko-Varga G. , Horvatovich P. , Döme B., Schelch K., Rezeli M.”, Clin. Transl. Sci , 2022, 12, (9), e1060
    Impact Factor: 12.53
    
  • Lipid metabolic reprogramming in operable pancreatic cancer and tumor margin
    Pirhonen J., Szkalisity A., Hagström J., Kim Y., Migh E., Kovacs M., Hölttä M., Peränen J., Seppänen H., Haglund C., Gil J., Rezeli M., Malm J., Horvath P., Marko-Varga G., Puolakkainen P., Ikonen E., , Cancer Res, 2022, Nov 2;82(21):3932-3949
    Impact Factor: 14.099
    
  • Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small cell lung cancer: an international multicenter study
    Megyesfalvi Z., Barany N., Lantos A., Valko Z., Pipek O., Lang C., Schwendenwein A., Oberndorfer F., Paku S., Ferencz B., Fillinger J., Lohinai Z., Moldvay J., Galffy G., Rezeli M., Rivard C., Hirsch F. R., Brcic L., Popper H., Kern I., Kovacevic M., Skarda J., Mitták M., Marko-Varga G, Bogos K, Renyi-Vamos F., Hoda A. M., Klikovits T., Hoetzenecker K., Schelch K., Laszlo V., Dome B., J. Pathology, 2022, Aug;257(5):674-686
    Impact Factor: 7.99
    
  • Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
    Governa, Talbot, Gonçalves de Oliveira K, Cerezo Magaña, Bång Rudenstam, Johansson, Månsson, Forsberg Nilsson K, Marko Varga G, Enríquez Pérez J, Darabi A, Malmström J Bengzon J, Welinder C, Belting M., PNAS , 2022, 119 (9) e2114456119
    Impact Factor: 11.205
    
  • The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition.
    Hegedüs L., Livingstone E. Bánkfalvi A., Viehof J., Enyedi A., Bilecz A., Győrffy B., Baranyi M., Tőkés A-M, Gil J., Marko‐varga, G., Griewank K. G., Zimmer L., Váraljai R., Sucker A., Dirk Schadendorf Z. A., Aigner C. and Hegedüs B., 2022, In: Int. J. Mol. Sci., 2022, 23, 6, 3324 
    

  2021

  • Matrix assisted laser desorption ionization – mass spectrometry imaging of erlotinib reveals a new cause of drug resistance in a non-small-cell lung cancer mouse xenograft model
    Kim T. Y., Lee B., Kim Y., Sugihara Y., Rezeli M., Szasz A. M., Dome B., Marko‐varga, G., Kwon H.J., 2021 Jul., In: Translational Medicine. 11, 7, e481.
    
  • Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion
    Gil, J., Szeitz B., Kim, Y., Doma V., Çakır U., Almeida, N., Hagemeijer Y., Guryev V., Johansson J. G., SharmaY., Pla I., Horvath Z., de Siqueira Guedes J., Monnerat G., Reis Alves Carneiro G., Nogueira F., Lee B., Henriett Oskolas, Sugihara, Y., Kuras M., Roger Appelqvist, Wieslander E., Domont G. B., Baldetorp, B., Hong R., Timar J., Fenyö D., Betancourt L. H., Jakobsson J., Malm, J., Sanchez, A., A. Marcell Szasz, Horvatovich P., Rezeli, M., Karpati S., and Marko‐varga, G., 2021, In: Bio-RXiv, 2021,
    
  • An observational study on the molecular profiling of primary melanomas reveals a progression dependence on mitochondrial activation
    Gil, J., Rezeli, M., Lutz, E. G., Kim, Y., Sugihara, Y., Malm, J., Semenov, Y. R., Yu, K. H., Nguyen, N., Wan, G., Kemény, L. V., Kárpáti, S., Németh, I.B. & Marko‐varga, G., 2021 Dec., In: Cancers. 13 , 23, 6066.
    
  • Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
    Berta, J., Török, S., Tárnoki-Zách, J., Drozdovszky, O., Tóvári, J., Paku, S., Kovács, I., Czirók, A., Masri, B., Megyesfalvi, Z., Oskolás, H., Malm, J., Ingvar, C., Markó-Varga, G., Döme, B. & László, V., 2021, In: Scientific Reports. 11, 1, 5798.
    
  • Deep proteomic analysis on biobanked paraffine-archived melanoma with prognostic/predictive biomarker read-out
    Szadai, L., Velasquez, E., Szeitz, B., de Almeida, N. P., Domont, G., Betancourt, L. H., Gil, J., Marko-Varga, M., Oskolas, H., Jánosi, Á. J., Boyano-Adánez, M. D.C., Kemény, L., Baldetorp, B., Malm, J., Horvatovich, P., Szász, A.M., Németh, I.B. & Marko-Varga, G., 2021 Dec., In: Cancers. 13, 23, 6105.
    
  • Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact
    Cho, S.M., Kim, Y., Jung, Y., Ko, M., Marko-Varga, G. & Kwon, H. J., 2021 Nov., In: Journal of Medicinal Chemistry. 64, 21, p. 15858-15867 10 p.
    
  • Mapping the melanoma plasma proteome (MPP) using single-shot proteomics interfaced with the WiMT database
    Almeida, N., Rodriguez, J., Parada, I. P., Perez-Riverol, Y., Woldmar, N., Kim, Y., Oskolas, H., Betancourt, L., Valdés, J. G., Sahlin, K.B., Pizzatti, L., Szasz, A.M., Kárpáti, S., Appelqvist, R., Malm, J., Domont, G.B., Nogueira, F.C. S., Marko-Varga, G. & Sanchez, A., 2021 Dec. 1, In: Cancers. 13, 24, 6224.
  • Organ specific copy number variations in visceral metastases of human melanoma
    Papp, O., Doma, V., Gil, J., Markó-Varga, G., Kárpáti, S., Tímár, J. & Vízkeleti, L., 2021 Dec., In: Cancers. 13, 23, 5984.
  • Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data
    Sánchez Brotons, A., Eriksson, J. O., Kwiatkowski, M., Wolters, J.C., Kema, I. P., Barcaru, A., Kuipers, F., Bakker, S. J. L., Bischoff, R., Suits, F. & Horvatovich, P., 2021 Aug. 17, In: Analytical Chemistry. 93, 32, p. 11215-11224 10 p.
  • Proteomic Workflows for High-Quality Quantitative Proteome and Post-Translational Modification Analysis of Clinically Relevant Samples from Formalin-Fixed Paraffin-Embedded Archives
    Kuras, M., Woldmar, N., Kim, Y., Hefner, M., Malm, J., Moldvay, J., Dome, B., Fillinger, J., Pizzatti, L., Gil, J., Marko-Varga, G. & Rezeli, M., 2021, In: Journal of Proteome Research. 20, 1, pp. 1027–1039
  • The Human Melanoma Proteome Atlas-Complementing the melanoma transcriptome
    Betancourt, L. H., Gil, J., Sanchez, A., Kuras, M., Velasquez, E., Kim, Y., Sugihara, Y., Parada, I. P., Appelqvist, R., Wieslander, E., Welinder, C., de Almeida, N. P., Woldmar, N., Marko-Varga, M., Eriksson, J., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Lindberg, H.& 15 others, , 2021, In: Clinical and Translational Medicine. 11, 7, pp. 1-25 e451.
  • The human melanoma proteome atlas-Defining the molecular pathology
    Betancourt, L. H., Gil, J., Kim, Y., Doma, V., Çakır, U., Sanchez, A., Murillo, J. R., Kuras, M., Parada, I. P., Sugihara, Y., Appelqvist, R., Wieslander, E., Welinder, C., Velasquez, E., de Almeida, N. P., Woldmar, N. , Marko-Varga, M., Pawłowski, K., Eriksson, J., Szeitz, B. & 37 others, , 2021, In: Clinical and Translational Medicine. 11, 7, pp. 1-20 e473.

  2020

  • MSIWarp: A General Approach to Mass Alignment in Mass Spectrometry Imaging
    Eriksson, J. O., Sánchez Brotons, A., Rezeli, M., Suits, F., Markó-Varga, G. & Horvatovich, P., 2020, In: Analytical Chemistry. 92, 24, pp. 16138–16148
  • Novel functional proteins coded by the human genome discovered in metastases of melanoma patients
    Sanchez, A., Kuras, M., Murillo, J. R., Pla, I., Pawlowski, K., Szasz, A.M., Gil, J., Nogueira, F.C. S., Perez-Riverol, Y., Eriksson, J., Appelqvist, R., Miliotis, T., Kim, Y., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Ekedahl, H., Horvatovich, P., Sugihara, Y.& 8 others, , 2020 June, In: Cell Biology and Toxicology. 36, 3, p. 261-272 12 p.
  • Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes
    Kim, Y., Gil, J., Pla, I., Sanchez, A., Betancourt, L. H., Lee, B., Appelqvist, R., Ingvar, C., Lundgren, L., Olsson, H., Baldetorp, B., Kwon, H. J., Oskolás, H., Rezeli, M., Doma, V., Kárpáti, S. , Szasz, A.M., Németh, I.B., Malm, J. & Marko-Varga, G., 2020 Mar 24, In: Cancers. 12, 3, 767.
  • A biobanking turning-point in the use of formalin-fixed, paraffin tumor blocks to unveil kinase signaling in melanoma
    A biobanking turning-point in the use of formalin-fixed, paraffin tumor blocks to unveil kinase signaling in melanoma
    Velasquez, E., Szadai, L., Zhou, Q., Kim, Y., Pla, I., Sanchez, A., Appelqvist, R., Oskolas, H., Marko-Varga, M., Lee, B., Kwon, H. J., Malm, J., Szász, A.M., Gil, J., Betancourt, L. H., Németh, I.B. & Marko-Varga, G., 2021, In: Clinical and Translational Medicine. 11, 8, p. 1-6 e466.
  • Matrix-assisted laser desorption ionization – mass spectrometry imaging of erlotinib reveals a limited tumor tissue distribution in a non-small-cell lung cancer mouse xenograft model
    Kim, T. Y., Lee, B., Kim, Y., Sugihara, Y., Rezeli, M., Szasz, A.M., Dome, B., Marko-Varga, G. & Kwon, H. J., 2021, In: Clinical and Translational Medicine. 11, 7, e481.
  • Targeting the hydrophilic regions of recombinant proteins by MS via in-solution buffer-free trypsin digestion
    Betancourt, L. H., Espinosa, L. A., Ramos, Y., Bequet-Romero, M., Rodríguez, E. N., Sánchez, A., Marko-Varga, G., González, L. J. & Besada, V., 2020 Jun 1, In: European Journal of Mass Spectrometry. 26, 3, p. 230-237 8 p.

  2019

  • Assessing Automated Sample Preparation Technologies for High-Throughput Proteomics of Frozen Well Characterized Tissues from Swedish Biobanks
    Kuras, M., Betancourt, L. H., Rezeli, M., Rodriguez, J., Szasz, M., Zhou, Q., Miliotis, T., Andersson, R. & Marko-Varga, G., 2019, In: Journal of Proteome Research. 18, 1, pp. 548–556 9 p.
  • Challenging the heterogeneity of disease presentation in malignant melanoma—impact on patient treatment
    Marcell Szasz, A., Malm, J., Rezeli, M., Sugihara, Y., Betancourt, L. H., Rivas, D., Gyorffy, B. & Marko-Varga, G., 2019, In: Cell Biology and Toxicology. 35, 1, p. 1-14
  • Clinical protein science in translational medicine targeting malignant melanoma
    Gil, J., Betancourt, L. H., Pla, I., Sanchez, A., Appelqvist, R., Miliotis, T., Kuras, M., Oskolas, H., Kim, Y., Horvath, Z., Eriksson, J., Berge, E., Burestedt, E., Jönsson, G., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Horvatovich, P., Murillo, J. R. & 18 others, , 2019, In: Cell Biology and Toxicology. 35, 4, p. 293-332
  • Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data
    Betancourt, L. H., Pawłowski, K., Eriksson, J., Szasz, A.M., Mitra, S., Pla, I., Welinder, C., Ekedahl, H., Broberg, P., Appelqvist, R., Yakovleva, M., Sugihara, Y., Miharada, K., Ingvar, C., Lundgren, L., Baldetorp, B., Olsson, H., Rezeli, M., Wieslander, E., Horvatovich, P. & 3 others, , 2019 March 26, In: Scientific Reports. 9, 1, 5154.
  • The hidden story of heterogeneous B-raf V600E mutation quantitative protein expression in metastatic melanoma—association with clinical outcome and tumor phenotypes
    Betancourt, L. H., Szasz, A. M., Kuras, M., Murillo, J. R., Sugihara, Y., Pla, I., Horvath, Z., Pawłowski, K., Rezeli, M., Miharada, K., Gil, J., Eriksson, J., Appelqvist, R., Miliotis, T., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Horvatovich, P., Welinder, C. & 8 andra, , 2019, I: Cancers. 11, 12, 1981.

  2018

  • Automated phosphopeptide enrichment from minute quantities of frozen malignant melanoma tissue
    Murillo, J. R., Kuras, M., Rezeli, M., Milliotis, T., Betancourt, L. & Marko-Varga, G., 2018 dec. 10, I: PLoS ONE. 13, 12, e0208562.
  • Endogenous expression mapping of malignant melanoma by mass spectrometry imaging
    Sugihara, Y., Rivas, D., Malm, J., Szasz, M., Kwon, H., Baldetorp, B., Olsson, H., Ingvar, C., Rezeli, M., Fehniger, T. E. & Marko-Varga, G., 2018 aug. 6, I: Clinical and Translational Medicine. 7, s. 1-9 22.
  • Quantitative Assessment of Urea In-Solution Lys-C/Trypsin Digestions Reveals Superior Performance at Room Temperature over Traditional Proteolysis at 37 °C.
    Betancourt, L., Sanchez, A., Pla Parada, I., Kuras, M., Zhou, Q., Andersson, R. & Marko-Varga, G., 2018 maj 29, I: Journal of Proteome Research. 17, 7, s. 2556−2561 6 s.